Skeletal Muscle Biomarkers

Following skeletal muscle injury, biomarkers including troponin-I, myoglobin, and FABP are released into the blood. Measurement of the levels of these proteins allows the extent of skeletal muscle damage to be determined. We manufacture a range of skeletal muscle biomarker ELISA kits and purified skeletal muscle biomarkers.

Skeletal muscle troponin-I ELISA kits specifically recognize the fast twitch isoform of skeletal muscle troponin-I and can be used to assess skeletal muscle damage in the presence of cardiac muscle injury. At present we offer kits for mouse, rat, and monkey skeletal muscle troponin-I.

In addition to the skeletal muscle troponin-I kits we also offer ELISA kits for myoglobin, fatty acid binding protein (FABP), and myosin light chain-1 (MLC-1) in serum or plasma of species including mice, rats, dogs, rabbits, pigs, and monkeys. Myoglobin, FABP, and MLC-1 are useful biomarkers of skeletal muscle damage. However, unlike skeletal muscle troponin-I, myoglobin and FABP are nonspecific because both are expressed in cardiac muscle as well as skeletal muscle. When using myoglobin and FABP as skeletal muscle biomarkers it is therefore important to exclude, or control for, cardiac damage. An advantage of myoglobin and FABP is that they are usually released into the blood at much higher levels than found for skeletal muscle troponin-I, facilitating easier detection.

Traditionally, creatine kinase has been used to measure skeletal muscle injury. We are therefore pleased to introduce kits for measurement of rat and pig CK-MM.

For pricing and specific product information please follow the links at the top of the page.